Assay Detail
Binding
CHEMBL3365973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at P2Y1 receptor in platelet-enriched human plasma assessed as 10 uM ADP-induced platelet aggregation preincubated for 1 min followed by ADP induction measured at 5 mins by aggregometric analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.60 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3314307 | — | — | 1 | 7.30 |
| CHEMBL3314296 | — | — | 1 | 7.10 |
| CHEMBL3314308 | — | — | 1 | 7.05 |
| CHEMBL3314305 | — | — | 1 | 7.05 |
| CHEMBL3314314 | — | — | 1 | 6.96 |
| CHEMBL3263056 | — | — | 1 | 6.89 |
| CHEMBL3314313 | — | — | 1 | 6.89 |
| CHEMBL3314320 | — | — | 1 | 6.85 |
| CHEMBL3314315 | — | — | 1 | 6.82 |
| CHEMBL3314316 | — | — | 1 | 6.80 |
| CHEMBL3314298 | — | — | 1 | 6.80 |
| CHEMBL3314301 | — | — | 1 | 6.80 |
| CHEMBL3314303 | — | — | 1 | 6.75 |
| CHEMBL3314295 | — | — | 1 | 6.75 |
| CHEMBL3314321 | — | — | 1 | 6.75 |
| CHEMBL3314309 | — | — | 1 | 6.72 |
| CHEMBL3314319 | — | — | 1 | 6.70 |
| CHEMBL3314299 | — | — | 1 | 6.68 |
| CHEMBL3314304 | — | — | 1 | 6.64 |
| CHEMBL3314300 | — | — | 1 | 6.64 |
| CHEMBL3314311 | — | — | 1 | 6.62 |
| CHEMBL3314297 | — | — | 1 | 6.62 |
| CHEMBL3314318 | — | — | 1 | 6.58 |
| CHEMBL3314312 | — | — | 1 | 6.52 |
| CHEMBL3314310 | — | — | 1 | 6.41 |
| CHEMBL3314302 | — | — | 1 | 6.40 |
| CHEMBL3314306 | — | — | 1 | 6.37 |
| CHEMBL3314291 | — | — | 1 | 6.21 |
| CHEMBL3314288 | — | — | 1 | 6.06 |
| CHEMBL3314317 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3314307 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3314296 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3314308 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3314305 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3314314 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3263056 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3314313 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3314320 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3314315 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3314316 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3314298 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3314301 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3314303 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3314295 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3314321 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3314309 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3314319 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3314299 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3314304 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3314300 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3314311 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3314297 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3314318 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3314312 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3314310 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3314302 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3314306 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3314291 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3314288 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3314317 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3314287 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3314289 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3314290 | — | IC50 | = | 3100.0 | nM | 5.51 |