Assay Detail
Binding
CHEMBL3366148
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Inhibition of HDAC8 (unknown origin) incubated at 37 degC for 30 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of class I HDAC isoform selectivity of largazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.45 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1796689 | LARGAZOLE THIOL | — | 1 | 6.99 |
| CHEMBL3317818 | — | — | 1 | 6.27 |
| CHEMBL3317817 | — | — | 1 | 6.10 |
| CHEMBL3317810 | — | — | 1 | - |
| CHEMBL3317811 | — | — | 1 | - |
| CHEMBL3317812 | — | — | 1 | - |
| CHEMBL3317813 | — | — | 1 | - |
| CHEMBL3317814 | — | — | 1 | - |
| CHEMBL3317815 | — | — | 1 | - |
| CHEMBL3317816 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1796689 | LARGAZOLE THIOL | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3317818 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3317817 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3317810 | — | IC50 | - | — | - | |
| CHEMBL3317811 | — | IC50 | - | — | - | |
| CHEMBL3317812 | — | IC50 | - | — | - | |
| CHEMBL3317813 | — | IC50 | - | — | - | |
| CHEMBL3317814 | — | IC50 | - | — | - | |
| CHEMBL3317815 | — | IC50 | - | — | - | |
| CHEMBL3317816 | — | IC50 | - | — | - |