Assay Detail
Binding
CHEMBL3366153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Ketanserin from human 5-HT2A receptor by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further evaluation of the tropane analogs of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.00 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.48 |
| CHEMBL210578 | — | — | 1 | 7.51 |
| CHEMBL1940404 | — | — | 1 | 7.14 |
| CHEMBL3321790 | — | — | 1 | 7.05 |
| CHEMBL1940403 | — | — | 1 | 7.03 |
| CHEMBL3321792 | — | — | 1 | 6.94 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.92 |
| CHEMBL3321789 | — | — | 1 | 6.63 |
| CHEMBL1940402 | — | — | 1 | 6.52 |
| CHEMBL3321788 | — | — | 1 | 6.50 |
| CHEMBL3321791 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL210578 | — | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL1940404 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL3321790 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL1940403 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3321792 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3321789 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL1940402 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL3321788 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL3321791 | — | Ki | = | 509.0 | nM | 6.29 |