Assay Detail
Binding
CHEMBL3366154
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Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further evaluation of the tropane analogs of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.24 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3321790 | — | — | 1 | 7.01 |
| CHEMBL3321789 | — | — | 1 | 6.38 |
| CHEMBL3321788 | — | — | 1 | 6.33 |
| CHEMBL1940404 | — | — | 1 | 6.18 |
| CHEMBL3321792 | — | — | 1 | 6.05 |
| CHEMBL3321791 | — | — | 1 | 6.04 |
| CHEMBL1940402 | — | — | 1 | 5.98 |
| CHEMBL1940403 | — | — | 1 | 5.98 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
| CHEMBL210578 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3321790 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL3321789 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3321788 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL1940404 | — | Ki | = | 656.0 | nM | 6.18 |
| CHEMBL3321792 | — | Ki | = | 882.0 | nM | 6.05 |
| CHEMBL3321791 | — | Ki | = | 917.0 | nM | 6.04 |
| CHEMBL1940402 | — | Ki | = | 1042.0 | nM | 5.98 |
| CHEMBL1940403 | — | Ki | = | 1044.0 | nM | 5.98 |
| CHEMBL54 | HALOPERIDOL | Ki | - | — | - | |
| CHEMBL210578 | — | Ki | - | — | - |