Assay Detail
Binding
CHEMBL3366162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further evaluation of the tropane analogs of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.05 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940403 | — | — | 1 | 6.94 |
| CHEMBL1940402 | — | — | 1 | 6.89 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.36 |
| CHEMBL1940404 | — | — | 1 | 6.16 |
| CHEMBL3321790 | — | — | 1 | 6.01 |
| CHEMBL3321792 | — | — | 1 | 6.00 |
| CHEMBL3321791 | — | — | 1 | 5.92 |
| CHEMBL3321788 | — | — | 1 | 5.76 |
| CHEMBL3321789 | — | — | 1 | 5.38 |
| CHEMBL210578 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940403 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL1940402 | — | Ki | = | 128.5 | nM | 6.89 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL1940404 | — | Ki | = | 698.6 | nM | 6.16 |
| CHEMBL3321790 | — | Ki | = | 977.0 | nM | 6.01 |
| CHEMBL3321792 | — | Ki | = | 1009.0 | nM | 6.00 |
| CHEMBL3321791 | — | Ki | = | 1207.0 | nM | 5.92 |
| CHEMBL3321788 | — | Ki | = | 1719.0 | nM | 5.76 |
| CHEMBL3321789 | — | Ki | = | 4149.0 | nM | 5.38 |
| CHEMBL210578 | — | Ki | = | 8780.0 | nM | 5.06 |