Assay Detail
Binding
CHEMBL3366167
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Displacement of [3H]Nisoxetine from human Norepinephrine transporter by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Further evaluation of the tropane analogs of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.81 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3321792 | — | — | 1 | 6.33 |
| CHEMBL3321791 | — | — | 1 | 6.29 |
| CHEMBL1940402 | — | — | 1 | 5.91 |
| CHEMBL3321790 | — | — | 1 | 5.85 |
| CHEMBL3321789 | — | — | 1 | 5.75 |
| CHEMBL1940403 | — | — | 1 | 5.65 |
| CHEMBL1940404 | — | — | 1 | 5.40 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.26 |
| CHEMBL210578 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3321792 | — | Ki | = | 462.0 | nM | 6.33 |
| CHEMBL3321791 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL1940402 | — | Ki | = | 1225.0 | nM | 5.91 |
| CHEMBL3321790 | — | Ki | = | 1409.0 | nM | 5.85 |
| CHEMBL3321789 | — | Ki | = | 1791.0 | nM | 5.75 |
| CHEMBL1940403 | — | Ki | = | 2249.0 | nM | 5.65 |
| CHEMBL1940404 | — | Ki | = | 3959.0 | nM | 5.40 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL210578 | — | Ki | - | — | - |