Assay Detail
Binding
CHEMBL3366360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.74 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3329621 | — | — | 1 | 10.00 |
| CHEMBL3329622 | — | — | 1 | 9.70 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3329621 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3329622 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 0.3 | nM | 9.52 |