Assay Detail
ADMET
CHEMBL3366477
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Cytotoxicity against concanavalin-A stimulated human PBMC after 72 hrs by alamar blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.45 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.03 |
| CHEMBL3311279 | — | — | 1 | 4.65 |
| CHEMBL3311277 | — | — | 1 | 4.62 |
| CHEMBL3311278 | — | — | 1 | 4.53 |
| CHEMBL3311280 | — | — | 1 | 4.12 |
| CHEMBL3311281 | — | — | 1 | 4.11 |
| CHEMBL489140 | KAURENOIC ACID | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9360.0 | nM | 5.03 |
| CHEMBL3311279 | — | IC50 | = | 22520.0 | nM | 4.65 |
| CHEMBL3311277 | — | IC50 | = | 23820.0 | nM | 4.62 |
| CHEMBL3311278 | — | IC50 | = | 29350.0 | nM | 4.53 |
| CHEMBL3311280 | — | IC50 | = | 75700.0 | nM | 4.12 |
| CHEMBL3311281 | — | IC50 | = | 78560.0 | nM | 4.11 |
| CHEMBL489140 | KAURENOIC ACID | IC50 | = | 80770.0 | nM | 4.09 |