Assay Detail
Functional
CHEMBL3366683
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.98 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323240 | — | — | 1 | 5.58 |
| CHEMBL3323241 | — | — | 1 | 5.28 |
| CHEMBL3323242 | — | — | 1 | 5.13 |
| CHEMBL3323245 | — | — | 1 | 5.05 |
| CHEMBL3323243 | — | — | 1 | 4.89 |
| CHEMBL3323246 | — | — | 1 | 4.81 |
| CHEMBL3323247 | — | — | 1 | 4.56 |
| CHEMBL3323244 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323240 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3323241 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3323242 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3323245 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3323243 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL3323246 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3323247 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL3323244 | — | IC50 | = | 30800.0 | nM | 4.51 |