Assay Detail
Binding
CHEMBL3366772
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Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEK-293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
G-protein coupled receptor homolog US28 (CHEMBL4259) ↗| Type | SINGLE PROTEIN |
| Organism | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Publication
Allosteric modulation of the G protein-coupled US28 receptor of human cytomegalovirus: are the small-weight inverse agonist of US28 'camouflaged' agonists?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.74 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | 2.0 | 2 | 6.46 |
| CHEMBL1824272 | — | — | 2 | 6.00 |
| CHEMBL1824269 | — | — | 2 | 5.82 |
| CHEMBL1824275 | — | — | 2 | 5.47 |
| CHEMBL1824270 | — | — | 2 | 5.36 |
| CHEMBL34166 | BERLEX COMPOUND | — | 2 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL93240 | METITEPINE | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL1824272 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1824272 | — | EC50 | = | 1023.29 | nM | 5.99 |
| CHEMBL1824269 | — | EC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL1824269 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1824275 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1824275 | — | EC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL1824270 | — | EC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL1824270 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL34166 | BERLEX COMPOUND | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL34166 | BERLEX COMPOUND | EC50 | = | 4570.88 | nM | 5.34 |