Assay Detail
Binding
CHEMBL3366798
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Inhibition of human aldosterone synthase expressed in V79 MZ cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZ |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.41 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3313977 | — | — | 1 | 9.82 |
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 9.70 |
| CHEMBL3313978 | — | — | 1 | 8.66 |
| CHEMBL3313969 | — | — | 1 | 8.38 |
| CHEMBL3313980 | — | — | 1 | 7.68 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3313977 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3313978 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3313969 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3313980 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 650.0 | nM | 6.19 |