Assay Detail
Functional
CHEMBL3366915
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Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.54 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.52 |
| CHEMBL591637 | — | — | 1 | 6.70 |
| CHEMBL470514 | — | — | 1 | 5.83 |
| CHEMBL3299078 | — | — | 1 | 5.83 |
| CHEMBL591362 | — | — | 1 | 5.80 |
| CHEMBL2028053 | — | — | 1 | - |
| CHEMBL597262 | — | — | 1 | - |
| CHEMBL537778 | — | — | 1 | - |
| CHEMBL3299076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL591637 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL470514 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3299078 | — | IC50 | = | 1475.0 | nM | 5.83 |
| CHEMBL591362 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2028053 | — | IC50 | - | — | - | |
| CHEMBL597262 | — | IC50 | - | — | - | |
| CHEMBL537778 | — | IC50 | - | — | - | |
| CHEMBL3299076 | — | IC50 | - | — | - |