Assay Detail
Binding
CHEMBL3367253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]EB from rat nAChR alpha7 expressed in HEK293 cell membranes by liquid scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.63 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1084615 | — | — | 1 | 6.17 |
| CHEMBL3318012 | — | — | 1 | 5.75 |
| CHEMBL3318010 | — | — | 1 | 5.64 |
| CHEMBL3318011 | — | — | 1 | 4.96 |
| CHEMBL3318013 | — | — | 1 | - |
| CHEMBL3318014 | — | — | 1 | - |
| CHEMBL3318015 | — | — | 1 | - |
| CHEMBL3318016 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1084615 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL3318012 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3318010 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3318011 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL3318013 | — | Ki | = | 216000.0 | nM | - |
| CHEMBL3318014 | — | Ki | = | 236000.0 | nM | - |
| CHEMBL3318015 | — | Ki | = | 165000.0 | nM | - |
| CHEMBL3318016 | — | Ki | = | 156000.0 | nM | - |