Assay Detail
Binding
CHEMBL3367256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat nAChR alpha7 expressed in GH4C1 cells by fluorescent calcium assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | GH4-C1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.82 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1084615 | — | — | 1 | 6.07 |
| CHEMBL3318010 | — | — | 1 | 5.76 |
| CHEMBL3318012 | — | — | 1 | 5.62 |
| CHEMBL3318011 | — | — | 1 | - |
| CHEMBL3318013 | — | — | 1 | - |
| CHEMBL3318014 | — | — | 1 | - |
| CHEMBL3318015 | — | — | 1 | - |
| CHEMBL3318016 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1084615 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3318010 | — | EC50 | = | 1746.0 | nM | 5.76 |
| CHEMBL3318012 | — | EC50 | = | 2374.0 | nM | 5.62 |
| CHEMBL3318011 | — | EC50 | - | — | - | |
| CHEMBL3318013 | — | EC50 | - | — | - | |
| CHEMBL3318014 | — | EC50 | - | — | - | |
| CHEMBL3318015 | — | EC50 | - | — | - | |
| CHEMBL3318016 | — | EC50 | - | — | - |