Assay Detail
Binding
CHEMBL3367287
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Inhibition of goat liver cathepsin H using Leu-betaNA substrate pre-incubated 30 mins before substrate addition by colorimetry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Capra hircus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.16 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3309617 | — | — | 1 | 5.24 |
| CHEMBL2143048 | — | — | 1 | 5.20 |
| CHEMBL3309799 | — | — | 1 | 5.16 |
| CHEMBL3309804 | — | — | 1 | 5.15 |
| CHEMBL332286 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3309617 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2143048 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL3309799 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3309804 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL332286 | — | IC50 | = | 9000.0 | nM | 5.05 |