Assay Detail
Binding
CHEMBL3367289
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Competitive inhibition of goat liver cathepsin H using Leu-betaNA substrate by Lineweaver-Burk plot analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Capra hircus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.46 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3309617 | — | — | 1 | 5.95 |
| CHEMBL2143048 | — | — | 1 | 5.93 |
| CHEMBL3309799 | — | — | 1 | 5.81 |
| CHEMBL3309795 | — | — | 1 | 5.77 |
| CHEMBL3309619 | — | — | 1 | 5.72 |
| CHEMBL2132758 | — | — | 1 | 5.67 |
| CHEMBL3309804 | — | — | 1 | 5.63 |
| CHEMBL3309806 | — | — | 1 | 5.59 |
| CHEMBL3309618 | — | — | 1 | 5.58 |
| CHEMBL3309794 | — | — | 1 | 5.54 |
| CHEMBL3309796 | — | — | 1 | 5.54 |
| CHEMBL3309797 | — | — | 1 | 5.50 |
| CHEMBL3309807 | — | — | 1 | 5.48 |
| CHEMBL3309801 | — | — | 1 | 5.48 |
| CHEMBL3309805 | — | — | 1 | 5.42 |
| CHEMBL2130993 | — | — | 1 | 5.38 |
| CHEMBL3309616 | — | — | 1 | 5.32 |
| CHEMBL3309800 | — | — | 1 | 5.27 |
| CHEMBL2136015 | — | — | 1 | 5.27 |
| CHEMBL1684781 | — | — | 1 | 5.22 |
| CHEMBL3309267 | — | — | 1 | 5.13 |
| CHEMBL3309802 | — | — | 1 | 5.09 |
| CHEMBL3309803 | — | — | 1 | 5.01 |
| CHEMBL2137785 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3309617 | — | Ki | = | 1111.0 | nM | 5.95 |
| CHEMBL2143048 | — | Ki | = | 1174.0 | nM | 5.93 |
| CHEMBL3309799 | — | Ki | = | 1562.0 | nM | 5.81 |
| CHEMBL3309795 | — | Ki | = | 1695.0 | nM | 5.77 |
| CHEMBL3309619 | — | Ki | = | 1905.0 | nM | 5.72 |
| CHEMBL2132758 | — | Ki | = | 2119.0 | nM | 5.67 |
| CHEMBL3309804 | — | Ki | = | 2346.0 | nM | 5.63 |
| CHEMBL3309806 | — | Ki | = | 2579.0 | nM | 5.59 |
| CHEMBL3309618 | — | Ki | = | 2658.0 | nM | 5.58 |
| CHEMBL3309794 | — | Ki | = | 2906.0 | nM | 5.54 |
| CHEMBL3309796 | — | Ki | = | 2907.0 | nM | 5.54 |
| CHEMBL3309797 | — | Ki | = | 3158.0 | nM | 5.50 |
| CHEMBL3309807 | — | Ki | = | 3330.0 | nM | 5.48 |
| CHEMBL3309801 | — | Ki | = | 3333.0 | nM | 5.48 |
| CHEMBL3309805 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL2130993 | — | Ki | = | 4184.0 | nM | 5.38 |
| CHEMBL3309616 | — | Ki | = | 4810.0 | nM | 5.32 |
| CHEMBL3309800 | — | Ki | = | 5376.0 | nM | 5.27 |
| CHEMBL2136015 | — | Ki | = | 5388.0 | nM | 5.27 |
| CHEMBL1684781 | — | Ki | = | 6024.0 | nM | 5.22 |
| CHEMBL3309267 | — | Ki | = | 7396.0 | nM | 5.13 |
| CHEMBL3309802 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL3309803 | — | Ki | = | 9804.0 | nM | 5.01 |
| CHEMBL2137785 | — | Ki | = | 18590.0 | nM | 4.73 |