Assay Detail
ADMET
CHEMBL3367490
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Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.73 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631465 | — | — | 1 | 5.07 |
| CHEMBL3322530 | — | — | 1 | 4.91 |
| CHEMBL3322527 | — | — | 1 | 4.87 |
| CHEMBL3322529 | — | — | 1 | 4.81 |
| CHEMBL155563 | — | — | 1 | 4.79 |
| CHEMBL3322521 | — | — | 1 | 4.68 |
| CHEMBL318782 | Dichlon | — | 1 | 4.64 |
| CHEMBL3322528 | — | — | 1 | 4.07 |
| CHEMBL3322526 | — | — | 1 | - |
| CHEMBL1723955 | — | — | 1 | - |
| CHEMBL3322531 | — | — | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631465 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3322530 | — | IC50 | = | 12280.0 | nM | 4.91 |
| CHEMBL3322527 | — | IC50 | = | 13590.0 | nM | 4.87 |
| CHEMBL3322529 | — | IC50 | = | 15530.0 | nM | 4.81 |
| CHEMBL155563 | — | IC50 | = | 16390.0 | nM | 4.79 |
| CHEMBL3322521 | — | IC50 | = | 20780.0 | nM | 4.68 |
| CHEMBL318782 | Dichlon | IC50 | = | 22990.0 | nM | 4.64 |
| CHEMBL3322528 | — | IC50 | = | 86050.0 | nM | 4.07 |
| CHEMBL3322526 | — | IC50 | - | — | - | |
| CHEMBL1723955 | — | IC50 | - | — | - | |
| CHEMBL3322531 | — | IC50 | - | — | - | |
| CHEMBL44657 | ETOPOSIDE | IC50 | - | — | - | |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - |