Assay Detail
Binding
CHEMBL3367530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CHK2 (unknown origin) by FRET-based homogenous assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.59 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330410 | — | — | 1 | 7.00 |
| CHEMBL3330260 | — | — | 1 | 6.39 |
| CHEMBL3330409 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330410 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3330260 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3330409 | — | IC50 | = | 420.0 | nM | 6.38 |