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Assay Detail

CHEMBL3367772

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Functional
Antimicrobial activity against promastigote stage of Leishmania donovani after 72 hrs by Alamar Blue assay
ChEMBL ↗
45
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367) ↗
Type ORGANISM
Organism Leishmania donovani

Publication

Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines.
Manda S, Khan SI, Jain SK, Mohammed S, Tekwani BL, Khan IA, Vishwakarma RA, Bharate SB.
Bioorg Med Chem Lett (2014) 24 : 3247 -3250
PubMed 24980054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 4.77 6.52
IC90 17 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 2 6.52
CHEMBL269538 HARMINE 1.0 1 5.43
CHEMBL55 PENTAMIDINE 4.0 2 5.32
CHEMBL3309545 — — 2 5.04
CHEMBL3309533 — — 2 4.90
CHEMBL3309543 — — 2 4.80
CHEMBL12014 HARMAN — 1 4.72
CHEMBL3309546 — — 2 4.66
CHEMBL3309538 — — 1 4.58
CHEMBL3309536 — — 1 4.56
CHEMBL3309544 — — 1 4.47
CHEMBL3309539 — — 2 4.40
CHEMBL3309535 — — 2 4.30
CHEMBL3309540 — — 1 4.28
CHEMBL3359596 — — 1 4.18
CHEMBL3309537 — — 2 4.12
CHEMBL3309542 — — 2 -
CHEMBL3309541 — — 1 -
CHEMBL830 EFLORNITHINE 4.0 1 -
CHEMBL440598 — — 1 -
CHEMBL340807 HARMALINE — 1 -
CHEMBL3309266 — — 2 -
CHEMBL3309708 — — 2 -
CHEMBL3309709 — — 2 -
CHEMBL3309710 — — 2 -
CHEMBL3309711 — — 2 -
CHEMBL3309712 — — 2 -
CHEMBL274656 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 300.0 nM 6.52
CHEMBL269538 HARMINE IC50 = 3700.0 nM 5.43
CHEMBL55 PENTAMIDINE IC50 = 4800.0 nM 5.32
CHEMBL3309545 — IC50 = 9100.0 nM 5.04
CHEMBL3309533 — IC50 = 12700.0 nM 4.90
CHEMBL3309543 — IC50 = 16000.0 nM 4.80
CHEMBL12014 HARMAN IC50 = 19200.0 nM 4.72
CHEMBL3309546 — IC50 = 22100.0 nM 4.66
CHEMBL3309538 — IC50 = 26000.0 nM 4.58
CHEMBL3309536 — IC50 = 27500.0 nM 4.56
CHEMBL3309544 — IC50 = 33800.0 nM 4.47
CHEMBL3309539 — IC50 = 39600.0 nM 4.40
CHEMBL3309535 — IC50 = 49500.0 nM 4.30
CHEMBL3309540 — IC50 = 52600.0 nM 4.28
CHEMBL3359596 — IC50 = 66700.0 nM 4.18
CHEMBL3309537 — IC50 = 75300.0 nM 4.12
CHEMBL3309533 — IC90 = 36600.0 nM -
CHEMBL3309535 — IC90 = 120200.0 nM -
CHEMBL3309537 — IC90 = 111200.0 nM -
CHEMBL3309539 — IC90 = 69100.0 nM -
CHEMBL440598 — IC50 = 121300.0 nM -
CHEMBL3309541 — IC50 = 117700.0 nM -
CHEMBL3309542 — IC50 - — -
CHEMBL3309543 — IC90 = 76000.0 nM -
CHEMBL3309545 — IC90 = 25600.0 nM -
CHEMBL3309546 — IC90 = 28100.0 nM -
CHEMBL55 PENTAMIDINE IC90 = 6100.0 nM -
CHEMBL267345 AMPHOTERICIN B IC90 = 400.0 nM -
CHEMBL830 EFLORNITHINE IC50 - — -
CHEMBL340807 HARMALINE IC50 = 116800.0 nM -
CHEMBL3309266 — IC50 - — -
CHEMBL3309708 — IC90 - — -
CHEMBL3309709 — IC90 - — -
CHEMBL3309710 — IC90 - — -
CHEMBL3309711 — IC90 - — -
CHEMBL3309712 — IC90 - — -
CHEMBL3309542 — IC90 - — -
CHEMBL274656 — IC90 - — -
CHEMBL274656 — IC50 - — -
CHEMBL3309712 — IC50 - — -
CHEMBL3309266 — IC90 - — -
CHEMBL3309711 — IC50 - — -
CHEMBL3309710 — IC50 - — -
CHEMBL3309709 — IC50 - — -
CHEMBL3309708 — IC50 - — -