Assay Detail
Functional
CHEMBL3367773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against axenic amastigote stage of Leishmania donovani after 72 hrs by Alamar Blue assay
49
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.05 | 6.64 |
| IC90 | 21 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269538 | HARMINE | 1.0 | 1 | 6.64 |
| CHEMBL12014 | HARMAN | — | 1 | 6.57 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 2 | 6.52 |
| CHEMBL340807 | HARMALINE | — | 1 | 5.94 |
| CHEMBL3309539 | — | — | 2 | 4.43 |
| CHEMBL3309533 | — | — | 2 | 4.20 |
| CHEMBL3309543 | — | — | 2 | 4.09 |
| CHEMBL3309537 | — | — | 2 | 4.08 |
| CHEMBL3309546 | — | — | 1 | 4.06 |
| CHEMBL3309536 | — | — | 2 | 4.01 |
| CHEMBL3359596 | — | — | 2 | - |
| CHEMBL3309535 | — | — | 1 | - |
| CHEMBL3309538 | — | — | 2 | - |
| CHEMBL3309540 | — | — | 2 | - |
| CHEMBL440598 | — | — | 2 | - |
| CHEMBL3309541 | — | — | 2 | - |
| CHEMBL3309542 | — | — | 2 | - |
| CHEMBL3309544 | — | — | 1 | - |
| CHEMBL3309545 | — | — | 2 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 2 | - |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | - |
| CHEMBL274656 | — | — | 2 | - |
| CHEMBL3309712 | — | — | 2 | - |
| CHEMBL3309266 | — | — | 2 | - |
| CHEMBL3309708 | — | — | 2 | - |
| CHEMBL3309709 | — | — | 2 | - |
| CHEMBL3309710 | — | — | 2 | - |
| CHEMBL3309711 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269538 | HARMINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL12014 | HARMAN | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL340807 | HARMALINE | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL3309539 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL3309533 | — | IC50 | = | 62800.0 | nM | 4.20 |
| CHEMBL3309543 | — | IC50 | = | 80400.0 | nM | 4.09 |
| CHEMBL3309537 | — | IC50 | = | 83400.0 | nM | 4.08 |
| CHEMBL3309546 | — | IC50 | = | 87590.0 | nM | 4.06 |
| CHEMBL3309536 | — | IC50 | = | 96500.0 | nM | 4.01 |
| CHEMBL3309540 | — | IC50 | - | — | - | |
| CHEMBL3309539 | — | IC90 | = | 76000.0 | nM | - |
| CHEMBL3309538 | — | IC50 | - | — | - | |
| CHEMBL3309537 | — | IC90 | = | 110000.0 | nM | - |
| CHEMBL3309536 | — | IC90 | = | 122400.0 | nM | - |
| CHEMBL3309535 | — | IC50 | = | 116200.0 | nM | - |
| CHEMBL3359596 | — | IC50 | - | — | - | |
| CHEMBL3309533 | — | IC90 | = | 107300.0 | nM | - |
| CHEMBL3309266 | — | IC50 | - | — | - | |
| CHEMBL3309541 | — | IC50 | - | — | - | |
| CHEMBL440598 | — | IC50 | - | — | - | |
| CHEMBL3309708 | — | IC50 | - | — | - | |
| CHEMBL3309542 | — | IC50 | - | — | - | |
| CHEMBL3309543 | — | IC90 | = | 103600.0 | nM | - |
| CHEMBL3309544 | — | IC50 | = | 116700.0 | nM | - |
| CHEMBL3309545 | — | IC50 | - | — | - | |
| CHEMBL55 | PENTAMIDINE | IC50 | > | 29400.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | IC90 | > | 29400.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | IC90 | = | 400.0 | nM | - |
| CHEMBL3309710 | — | IC90 | - | — | - | |
| CHEMBL274656 | — | IC90 | - | — | - | |
| CHEMBL3309709 | — | IC50 | - | — | - | |
| CHEMBL274656 | — | IC50 | - | — | - | |
| CHEMBL3309712 | — | IC50 | - | — | - | |
| CHEMBL3309711 | — | IC50 | - | — | - | |
| CHEMBL3309710 | — | IC50 | - | — | - | |
| CHEMBL830 | EFLORNITHINE | IC50 | - | — | - | |
| CHEMBL3309712 | — | IC90 | - | — | - | |
| CHEMBL3309711 | — | IC90 | - | — | - | |
| CHEMBL3359596 | — | IC90 | - | — | - | |
| CHEMBL3309709 | — | IC90 | - | — | - | |
| CHEMBL3309708 | — | IC90 | - | — | - | |
| CHEMBL3309266 | — | IC90 | - | — | - | |
| CHEMBL3309545 | — | IC90 | - | — | - | |
| CHEMBL3309542 | — | IC90 | - | — | - | |
| CHEMBL3309541 | — | IC90 | - | — | - | |
| CHEMBL440598 | — | IC90 | - | — | - | |
| CHEMBL3309540 | — | IC90 | - | — | - | |
| CHEMBL3309538 | — | IC90 | - | — | - |