Assay Detail
Functional
CHEMBL3367774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against promastigote stage of Leishmania donovani infected in human THP1 cells after 72 hrs by Alamar Blue assay
49
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.65 | 6.70 |
| IC90 | 24 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 2 | 6.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 2 | 5.70 |
| CHEMBL3309546 | — | — | 2 | 4.55 |
| CHEMBL3359596 | — | — | 2 | - |
| CHEMBL3309535 | — | — | 2 | - |
| CHEMBL3309536 | — | — | 2 | - |
| CHEMBL3309537 | — | — | 2 | - |
| CHEMBL3309538 | — | — | 2 | - |
| CHEMBL3309539 | — | — | 2 | - |
| CHEMBL3309540 | — | — | 2 | - |
| CHEMBL440598 | — | — | 2 | - |
| CHEMBL3309541 | — | — | 2 | - |
| CHEMBL3309542 | — | — | 2 | - |
| CHEMBL3309543 | — | — | 2 | - |
| CHEMBL3309533 | — | — | 2 | - |
| CHEMBL3309545 | — | — | 2 | - |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | - |
| CHEMBL3309266 | — | — | 2 | - |
| CHEMBL3309708 | — | — | 2 | - |
| CHEMBL3309709 | — | — | 2 | - |
| CHEMBL3309710 | — | — | 2 | - |
| CHEMBL3309711 | — | — | 2 | - |
| CHEMBL3309712 | — | — | 2 | - |
| CHEMBL274656 | — | — | 2 | - |
| CHEMBL3309544 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3309546 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL3309544 | — | IC50 | - | — | - | |
| CHEMBL3309711 | — | IC50 | - | — | - | |
| CHEMBL3359596 | — | IC50 | - | — | - | |
| CHEMBL3309535 | — | IC50 | - | — | - | |
| CHEMBL3309536 | — | IC50 | - | — | - | |
| CHEMBL3309537 | — | IC50 | - | — | - | |
| CHEMBL3309538 | — | IC50 | - | — | - | |
| CHEMBL3309539 | — | IC50 | - | — | - | |
| CHEMBL3309540 | — | IC50 | - | — | - | |
| CHEMBL440598 | — | IC50 | - | — | - | |
| CHEMBL3309541 | — | IC50 | - | — | - | |
| CHEMBL3309542 | — | IC50 | - | — | - | |
| CHEMBL3309543 | — | IC50 | - | — | - | |
| CHEMBL3309712 | — | IC50 | - | — | - | |
| CHEMBL3309545 | — | IC50 | - | — | - | |
| CHEMBL3309546 | — | IC90 | > | 32000.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | IC90 | = | 3100.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | IC90 | = | 500.0 | nM | - |
| CHEMBL830 | EFLORNITHINE | IC50 | - | — | - | |
| CHEMBL3309266 | — | IC50 | - | — | - | |
| CHEMBL3309708 | — | IC50 | - | — | - | |
| CHEMBL3309709 | — | IC50 | - | — | - | |
| CHEMBL3309533 | — | IC50 | - | — | - | |
| CHEMBL3309543 | — | IC90 | - | — | - | |
| CHEMBL3309544 | — | IC90 | - | — | - | |
| CHEMBL274656 | — | IC50 | - | — | - | |
| CHEMBL274656 | — | IC90 | - | — | - | |
| CHEMBL3309712 | — | IC90 | - | — | - | |
| CHEMBL3309711 | — | IC90 | - | — | - | |
| CHEMBL3309710 | — | IC90 | - | — | - | |
| CHEMBL3309709 | — | IC90 | - | — | - | |
| CHEMBL3309708 | — | IC90 | - | — | - | |
| CHEMBL3309266 | — | IC90 | - | — | - | |
| CHEMBL3309545 | — | IC90 | - | — | - | |
| CHEMBL3309710 | — | IC50 | - | — | - | |
| CHEMBL3309533 | — | IC90 | - | — | - | |
| CHEMBL3309542 | — | IC90 | - | — | - | |
| CHEMBL3309541 | — | IC90 | - | — | - | |
| CHEMBL440598 | — | IC90 | - | — | - | |
| CHEMBL3309540 | — | IC90 | - | — | - | |
| CHEMBL3309539 | — | IC90 | - | — | - | |
| CHEMBL3309538 | — | IC90 | - | — | - | |
| CHEMBL3309537 | — | IC90 | - | — | - | |
| CHEMBL3309536 | — | IC90 | - | — | - | |
| CHEMBL3309535 | — | IC90 | - | — | - | |
| CHEMBL3359596 | — | IC90 | - | — | - |