Assay Detail
Binding
CHEMBL3367868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium channel subfamily K member 3 (CHEMBL2321613) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3182449 | — | — | 1 | 8.00 |
| CHEMBL3187482 | — | — | 1 | 7.96 |
| CHEMBL1081188 | — | — | 1 | 7.80 |
| CHEMBL3182359 | — | — | 1 | 7.52 |
| CHEMBL3182725 | — | — | 1 | 7.22 |
| CHEMBL1310568 | — | — | 1 | 7.12 |
| CHEMBL3183773 | — | — | 1 | 6.43 |
| CHEMBL3187891 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3182449 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3187482 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1081188 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3182359 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3182725 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1310568 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3183773 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3187891 | — | IC50 | = | 2140.0 | nM | 5.67 |