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Assay Detail

CHEMBL3367910

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Plasmodium falciparum 3D7
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium.
Njuguna JT, von Koschitzky I, Gerhardt H, Lämmerhofer M, Choucry A, Pink M, Schmitz-Spahnke S, Bakheit MA, Strube C, Kaiser A.
Bioorg Med Chem (2014) 22 : 4338 -4346
PubMed 24909679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 3 6.80 7.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL587083 1 7.08
CHEMBL532879 1 6.85
CHEMBL547488 1 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL587083 EC50 = 82.2 nM 7.08
CHEMBL532879 EC50 = 142.0 nM 6.85
CHEMBL547488 EC50 = 345.0 nM 6.46