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Assay Detail

CHEMBL3368016

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Nav1.7 (unknown origin) by PatchXpress method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sodium channel protein type 9 subunit alpha (CHEMBL4296)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent progress in sodium channel modulators for pain.
Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA.
Bioorg Med Chem Lett (2014) 24 : 3690 -3699
PubMed 25060923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 8.77 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3341983 1 9.22
CHEMBL3341984 1 8.68
CHEMBL3341985 1 8.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3341983 IC50 = 0.6 nM 9.22
CHEMBL3341984 IC50 = 2.1 nM 8.68
CHEMBL3341985 IC50 = 3.8 nM 8.42