Assay Detail
Functional
CHEMBL3368401
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of Ospemifene analogs as anti-breast cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.48 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330031 | — | — | 1 | 4.77 |
| CHEMBL3330030 | — | — | 1 | 4.60 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.07 |
| CHEMBL3330032 | — | — | 1 | - |
| CHEMBL2105395 | OSPEMIFENE | 4.0 | 1 | - |
| CHEMBL3330028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330031 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3330030 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 84600.0 | nM | 4.07 |
| CHEMBL3330032 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2105395 | OSPEMIFENE | IC50 | > | 100000.0 | nM | - |
| CHEMBL3330028 | — | IC50 | > | 100000.0 | nM | - |