Assay Detail
Functional
CHEMBL3368404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of Ospemifene analogs as anti-breast cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.52 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330031 | — | — | 1 | 4.95 |
| CHEMBL3330030 | — | — | 1 | 4.91 |
| CHEMBL3330032 | — | — | 1 | 4.30 |
| CHEMBL2105395 | OSPEMIFENE | 4.0 | 1 | 4.26 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.19 |
| CHEMBL3330028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330031 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3330030 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3330032 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2105395 | OSPEMIFENE | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 64300.0 | nM | 4.19 |
| CHEMBL3330028 | — | IC50 | > | 100000.0 | nM | - |