Assay Detail
Binding
CHEMBL3368556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged human brain tau 3R MBD aggregation after 16 hrs by thioflavin T fluorescence method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Microtubule-associated protein tau (CHEMBL1293224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.94 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330753 | — | — | 1 | 6.52 |
| CHEMBL3330754 | — | — | 1 | 5.80 |
| CHEMBL3330737 | — | — | 1 | 5.77 |
| CHEMBL191083 | METHYLENE BLUE CATION | 4.0 | 1 | 5.66 |
| CHEMBL3330738 | — | — | 1 | - |
| CHEMBL3330739 | — | — | 1 | - |
| CHEMBL3330740 | — | — | 1 | - |
| CHEMBL3330741 | — | — | 1 | - |
| CHEMBL3330742 | — | — | 1 | - |
| CHEMBL3330743 | — | — | 1 | - |
| CHEMBL3330744 | — | — | 1 | - |
| CHEMBL3330745 | — | — | 1 | - |
| CHEMBL3330746 | — | — | 1 | - |
| CHEMBL3330747 | — | — | 1 | - |
| CHEMBL3330748 | — | — | 1 | - |
| CHEMBL3330749 | — | — | 1 | - |
| CHEMBL3330750 | — | — | 1 | - |
| CHEMBL3330751 | — | — | 1 | - |
| CHEMBL3330752 | — | — | 1 | - |
| CHEMBL3330735 | — | — | 1 | - |
| CHEMBL3330736 | — | — | 1 | - |
| CHEMBL164 | MYRICETIN | — | 1 | - |
| CHEMBL253570 | GOSSYPETIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330753 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3330754 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3330737 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL191083 | METHYLENE BLUE CATION | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3330738 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330739 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330740 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330741 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330742 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330743 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330744 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330745 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330746 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330747 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330748 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330749 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330750 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330751 | — | IC50 | < | 290.0 | nM | - |
| CHEMBL3330752 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330735 | — | IC50 | < | 3000.0 | nM | - |
| CHEMBL3330736 | — | IC50 | < | 3000.0 | nM | - |
| CHEMBL164 | MYRICETIN | IC50 | < | 3000.0 | nM | - |
| CHEMBL253570 | GOSSYPETIN | IC50 | < | 3000.0 | nM | - |