Assay Detail
Functional
CHEMBL3368562
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Anticancer activity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a]phthalazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.60 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330922 | — | — | 1 | 5.47 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.34 |
| CHEMBL3113524 | — | — | 1 | 4.73 |
| CHEMBL3330927 | — | — | 1 | 4.60 |
| CHEMBL3330767 | — | — | 1 | 4.56 |
| CHEMBL3330924 | — | — | 1 | 4.53 |
| CHEMBL3330766 | — | — | 1 | 4.33 |
| CHEMBL3330765 | — | — | 1 | 4.31 |
| CHEMBL3330763 | — | — | 1 | 4.07 |
| CHEMBL3330764 | — | — | 1 | 4.07 |
| CHEMBL3330755 | — | — | 1 | - |
| CHEMBL3330926 | — | — | 1 | - |
| CHEMBL3330925 | — | — | 1 | - |
| CHEMBL3330756 | — | — | 1 | - |
| CHEMBL3330923 | — | — | 1 | - |
| CHEMBL3330757 | — | — | 1 | - |
| CHEMBL3330921 | — | — | 1 | - |
| CHEMBL13408 | — | — | 1 | - |
| CHEMBL3330758 | — | — | 1 | - |
| CHEMBL3330759 | — | — | 1 | - |
| CHEMBL3330760 | — | — | 1 | - |
| CHEMBL3113529 | — | — | 1 | - |
| CHEMBL3330762 | — | — | 1 | - |
| CHEMBL3330761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330922 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3113524 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3330927 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL3330767 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL3330924 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL3330766 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL3330765 | — | IC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL3330763 | — | IC50 | = | 84300.0 | nM | 4.07 |
| CHEMBL3330764 | — | IC50 | = | 85400.0 | nM | 4.07 |
| CHEMBL3330755 | — | IC50 | = | 108500.0 | nM | - |
| CHEMBL3330926 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3330925 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3330756 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3330923 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3330757 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3330921 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL13408 | — | IC50 | = | 101500.0 | nM | - |
| CHEMBL3330758 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3330759 | — | IC50 | = | 107500.0 | nM | - |
| CHEMBL3330760 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3113529 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL3330762 | — | IC50 | = | 118300.0 | nM | - |
| CHEMBL3330761 | — | IC50 | > | 128000.0 | nM | - |