Assay Detail
Binding
CHEMBL3369124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D4.4 receptor stably expressed in CHO cell membranes by competitive binding assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D(2)-like receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.01 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318824 | — | — | 1 | 8.60 |
| CHEMBL1200986 | HALOPERIDOL DECANOATE | 4.0 | 1 | 8.24 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.23 |
| CHEMBL3318848 | — | — | 1 | 8.06 |
| CHEMBL3318845 | — | — | 1 | 8.03 |
| CHEMBL3318849 | — | — | 1 | 7.72 |
| CHEMBL3318831 | — | — | 1 | 7.62 |
| CHEMBL3318847 | — | — | 1 | 7.54 |
| CHEMBL3318832 | — | — | 1 | 7.48 |
| CHEMBL3318846 | — | — | 1 | 7.48 |
| CHEMBL3317465 | — | — | 1 | 7.39 |
| CHEMBL3318833 | — | — | 1 | 7.39 |
| CHEMBL3318851 | — | — | 1 | 7.34 |
| CHEMBL3318850 | — | — | 1 | 7.05 |
| CHEMBL3318844 | — | — | 1 | 6.89 |
| CHEMBL3318842 | — | — | 1 | 6.80 |
| CHEMBL3318835 | — | — | 1 | 6.52 |
| CHEMBL3318834 | — | — | 1 | 6.44 |
| CHEMBL3318839 | — | — | 1 | 6.31 |
| CHEMBL3318837 | — | — | 1 | 6.31 |
| CHEMBL3318836 | — | — | 1 | 6.28 |
| CHEMBL3318841 | — | — | 1 | 6.24 |
| CHEMBL3318843 | — | — | 1 | 6.07 |
| CHEMBL3318840 | — | — | 1 | 5.85 |
| CHEMBL3318838 | — | — | 1 | 5.66 |
| CHEMBL3318852 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318824 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1200986 | HALOPERIDOL DECANOATE | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3318848 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3318845 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL3318849 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3318831 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3318847 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3318832 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3318846 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3317465 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3318833 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3318851 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3318850 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL3318844 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3318842 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3318835 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3318834 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL3318839 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL3318837 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL3318836 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL3318841 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL3318843 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL3318840 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3318838 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3318852 | — | Ki | = | 18000.0 | nM | 4.75 |