Assay Detail
Binding
CHEMBL3369173
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Agonist activity at RoRc-LBD (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 reporter assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.49 | 9.00 |
| IC50 | 3 | 4.82 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3314002 | — | — | 1 | 9.00 |
| CHEMBL3314001 | — | — | 1 | 8.00 |
| CHEMBL3313999 | — | — | 1 | 7.89 |
| CHEMBL3314000 | — | — | 1 | 7.80 |
| CHEMBL3313998 | — | — | 1 | 7.40 |
| CHEMBL2137199 | — | — | 1 | 6.50 |
| CHEMBL3218917 | — | — | 1 | 5.82 |
| CHEMBL3314005 | — | — | 1 | 4.82 |
| CHEMBL3314004 | — | — | 1 | 4.82 |
| CHEMBL3314003 | — | — | 1 | 4.82 |
| CHEMBL3313997 | — | — | 1 | - |
| CHEMBL3313996 | — | — | 1 | - |
| CHEMBL3313995 | — | — | 1 | - |
| CHEMBL3355081 | — | — | 1 | - |
| CHEMBL3313993 | — | — | 1 | - |
| CHEMBL3313992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3314002 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3314001 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3313999 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3314000 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3313998 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2137199 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3218917 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3314005 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3314004 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3314003 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3313997 | — | EC50 | < | 500.0 | nM | - |
| CHEMBL3313996 | — | EC50 | < | 500.0 | nM | - |
| CHEMBL3313995 | — | EC50 | < | 500.0 | nM | - |
| CHEMBL3355081 | — | EC50 | < | 500.0 | nM | - |
| CHEMBL3313993 | — | EC50 | < | 500.0 | nM | - |
| CHEMBL3313992 | — | EC50 | < | 500.0 | nM | - |