Assay Detail
Binding
CHEMBL3369183
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Activity at human RoRc in human Jurkat cells assessed as inhibition of IL-17 promoter
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.13 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3314018 | — | — | 1 | 9.00 |
| CHEMBL3314017 | — | — | 1 | 9.00 |
| CHEMBL3314016 | — | — | 1 | 9.00 |
| CHEMBL3314015 | — | — | 1 | 9.00 |
| CHEMBL3105681 | — | — | 1 | 8.00 |
| CHEMBL3105692 | — | — | 1 | 7.60 |
| CHEMBL3314014 | — | — | 1 | 6.80 |
| CHEMBL3105674 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3314018 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3314017 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3314016 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3314015 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3105681 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3105692 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3314014 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3105674 | — | EC50 | = | 251.0 | nM | 6.60 |