Assay Detail
Binding
CHEMBL3369563
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Binding affinity to human His-tagged PPARgamma LBD by SPR method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPARγ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 9.29 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3317860 | — | — | 1 | 10.00 |
| CHEMBL3317867 | — | — | 1 | 9.96 |
| CHEMBL3317863 | — | — | 1 | 9.40 |
| CHEMBL3317865 | — | — | 1 | 9.39 |
| CHEMBL3317864 | — | — | 1 | 9.19 |
| CHEMBL3317866 | — | — | 1 | 9.10 |
| CHEMBL3317455 | — | — | 1 | 8.74 |
| CHEMBL3317858 | — | — | 1 | 8.54 |
| CHEMBL1651239 | — | — | 1 | - |
| CHEMBL3317862 | — | — | 1 | - |
| CHEMBL3317861 | — | — | 1 | - |
| CHEMBL3317859 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3317860 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL3317867 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL3317863 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL3317865 | — | Kd | = | 0.41 | nM | 9.39 |
| CHEMBL3317864 | — | Kd | = | 0.64 | nM | 9.19 |
| CHEMBL3317866 | — | Kd | = | 0.8 | nM | 9.10 |
| CHEMBL3317455 | — | Kd | = | 1.82 | nM | 8.74 |
| CHEMBL3317858 | — | Kd | = | 2.85 | nM | 8.54 |
| CHEMBL1651239 | — | Kd | - | — | - | |
| CHEMBL3317862 | — | Kd | - | — | - | |
| CHEMBL3317861 | — | Kd | - | — | - | |
| CHEMBL3317859 | — | Kd | - | — | - |