Assay Detail
Functional
CHEMBL3369648
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Antiproliferative activity against human NCI-H441 cells assessed as HGF-induced proliferation after 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H441 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.99 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3334567 | SAVOLITINIB | 3.0 | 1 | 8.22 |
| CHEMBL3334569 | — | — | 1 | 7.80 |
| CHEMBL3334556 | — | — | 1 | 7.60 |
| CHEMBL3334557 | — | — | 1 | 7.18 |
| CHEMBL3334551 | — | — | 1 | 7.18 |
| CHEMBL3334552 | — | — | 1 | 7.16 |
| CHEMBL3334542 | — | — | 1 | 7.14 |
| CHEMBL3334564 | — | — | 1 | 7.14 |
| CHEMBL3334561 | — | — | 1 | 7.11 |
| CHEMBL3334540 | — | — | 1 | 6.98 |
| CHEMBL3334568 | — | — | 1 | 6.95 |
| CHEMBL3334565 | — | — | 1 | 6.94 |
| CHEMBL3334570 | — | — | 1 | 6.78 |
| CHEMBL3334562 | — | — | 1 | 6.76 |
| CHEMBL3334541 | — | — | 1 | 6.75 |
| CHEMBL3334560 | — | — | 1 | 6.75 |
| CHEMBL3334546 | — | — | 1 | 6.74 |
| CHEMBL3334550 | — | — | 1 | 6.74 |
| CHEMBL3334563 | — | — | 1 | 6.69 |
| CHEMBL3334549 | — | — | 1 | 6.54 |
| CHEMBL3334544 | — | — | 1 | 6.37 |
| CHEMBL3334545 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3334567 | SAVOLITINIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3334569 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3334556 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3334557 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3334551 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3334552 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3334542 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3334564 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3334561 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3334540 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3334568 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3334565 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3334570 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL3334562 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL3334541 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3334560 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL3334546 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3334550 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL3334563 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3334549 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL3334544 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL3334545 | — | IC50 | = | 443.0 | nM | 6.35 |