Assay Detail
Binding
CHEMBL3369749
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Inhibition of HCV1b NS5B polymerase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.41 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120779 | — | — | 1 | 6.54 |
| CHEMBL438605 | — | — | 1 | 5.78 |
| CHEMBL3309899 | — | — | 1 | 4.75 |
| CHEMBL3309900 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120779 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL438605 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL3309899 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL3309900 | — | IC50 | = | 27000.0 | nM | 4.57 |