Assay Detail
Functional
CHEMBL3369751
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Antiviral activity against HCV1a assessed as inhibition of viral replication by cell based 384 well format assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.85 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120793 | GS-6620 | 1.0 | 1 | 7.03 |
| CHEMBL3309902 | — | — | 1 | 6.60 |
| CHEMBL3309901 | — | — | 1 | 5.92 |
| CHEMBL438605 | — | — | 1 | 5.60 |
| CHEMBL3309899 | — | — | 1 | 4.12 |
| CHEMBL3120779 | — | — | 1 | - |
| CHEMBL3309900 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120793 | GS-6620 | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3309902 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3309901 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL438605 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3309899 | — | EC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL3120779 | — | EC50 | > | 89000.0 | nM | - |
| CHEMBL3309900 | — | EC50 | > | 89000.0 | nM | - |