Assay Detail
Binding
CHEMBL3369753
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Inhibition of recombinant HIV-1 integrase by strand-transfer assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.07 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310085 | — | — | 1 | 8.52 |
| CHEMBL3310087 | — | — | 1 | 8.40 |
| CHEMBL3310093 | — | — | 1 | 8.39 |
| CHEMBL3310078 | — | — | 1 | 8.36 |
| CHEMBL3309906 | — | — | 1 | 8.36 |
| CHEMBL3310413 | — | — | 1 | 8.33 |
| CHEMBL3310084 | — | — | 1 | 8.24 |
| CHEMBL3310086 | — | — | 1 | 8.24 |
| CHEMBL3310409 | — | — | 1 | 8.21 |
| CHEMBL3310090 | — | — | 1 | 8.19 |
| CHEMBL3310082 | — | — | 1 | 8.17 |
| CHEMBL3310079 | — | — | 1 | 8.16 |
| CHEMBL3310081 | — | — | 1 | 8.15 |
| CHEMBL3310089 | — | — | 1 | 8.15 |
| CHEMBL3310097 | — | — | 1 | 8.14 |
| CHEMBL3310414 | — | — | 1 | 8.12 |
| CHEMBL3309903 | — | — | 1 | 8.12 |
| CHEMBL3310095 | — | — | 1 | 8.11 |
| CHEMBL3310077 | — | — | 1 | 8.11 |
| CHEMBL3310080 | — | — | 1 | 8.10 |
| CHEMBL1256978 | GSK-364735 | 2.0 | 1 | 8.09 |
| CHEMBL3309268 | — | — | 1 | 8.09 |
| CHEMBL3310094 | — | — | 1 | 8.07 |
| CHEMBL3310088 | — | — | 1 | 8.07 |
| CHEMBL3310098 | — | — | 1 | 8.07 |
| CHEMBL3310096 | — | — | 1 | 8.05 |
| CHEMBL3310076 | — | — | 1 | 8.04 |
| CHEMBL3310092 | — | — | 1 | 8.04 |
| CHEMBL3309905 | — | — | 1 | 8.03 |
| CHEMBL3309904 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310085 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3310087 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3310093 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3310078 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3309906 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3310413 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3310084 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3310086 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3310409 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3310090 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3310082 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3310079 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3310081 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3310089 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3310097 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3310414 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3309903 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3310077 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3310095 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3310080 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1256978 | GSK-364735 | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3309268 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3310094 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3310088 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3310098 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3310096 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3310092 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL3310076 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL3309905 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3309904 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3310410 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3309907 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3310083 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3310091 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3310415 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3310412 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3310411 | — | IC50 | = | 45.0 | nM | 7.35 |