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Assay Detail

CHEMBL3370046

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against schizont blood stage Plasmodium falciparum
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages.
Zou B, Nagle A, Chatterjee AK, Leong SY, Tan LJ, Sim WL, Mishra P, Guntapalli P, Tully DC, Lakshminarayana SB, Lim CS, Tan YC, Abas SN, Bodenreider C, Kuhen KL, Gagaring K, Borboa R, Chang J, Li C, Hollenbeck T, Tuntland T, Zeeman AM, Kocken CH, McNamara C, Kato N, Winzeler EA, Yeung BK, Diagana TT, Smith PW, Roland J.
ACS Med Chem Lett (2014) 5 : 947 -950
PubMed 25147620 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.84 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3325596 1 7.96
CHEMBL3325605 1 7.66
CHEMBL3325604 1 7.50
CHEMBL3325606 1 7.25
CHEMBL3325608 1 7.24
CHEMBL3325597 1 7.20
CHEMBL3325607 1 6.88
CHEMBL3325598 1 6.56
CHEMBL3325595 1 6.22
CHEMBL3325599 1 5.79
CHEMBL3325601 1 5.02
CHEMBL3325603 1 -
CHEMBL3325602 1 -
CHEMBL3325600 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3325596 IC50 = 11.0 nM 7.96
CHEMBL3325605 IC50 = 22.0 nM 7.66
CHEMBL3325604 IC50 = 32.0 nM 7.50
CHEMBL3325606 IC50 = 56.0 nM 7.25
CHEMBL3325608 IC50 = 58.0 nM 7.24
CHEMBL3325597 IC50 = 63.0 nM 7.20
CHEMBL3325607 IC50 = 131.0 nM 6.88
CHEMBL3325598 IC50 = 275.0 nM 6.56
CHEMBL3325595 IC50 = 600.0 nM 6.22
CHEMBL3325599 IC50 = 1630.0 nM 5.79
CHEMBL3325601 IC50 = 9580.0 nM 5.02
CHEMBL3325603 IC50 > 10000.0 nM -
CHEMBL3325602 IC50 > 10000.0 nM -
CHEMBL3325600 IC50 > 10000.0 nM -