Assay Detail
Functional
CHEMBL3370048
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Antiplasmodial activity against schizont liver stage Plasmodium cynomolgi
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium cynomolgi |
| Tissue | Liver |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.94 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3325605 | — | — | 1 | 7.40 |
| CHEMBL3325607 | — | — | 1 | 7.09 |
| CHEMBL3325608 | — | — | 1 | 6.98 |
| CHEMBL3325597 | — | — | 1 | 6.92 |
| CHEMBL3325606 | — | — | 1 | 6.72 |
| CHEMBL3325604 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3325605 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3325607 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3325608 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL3325597 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3325606 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3325604 | — | IC50 | = | 300.0 | nM | 6.52 |