Assay Detail
Functional
CHEMBL3370212
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Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774.A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: synthesis, biological evaluation and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.60 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322658 | — | — | 1 | 4.97 |
| CHEMBL3322657 | — | — | 1 | 4.80 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | — | 1 | 4.78 |
| CHEMBL3322656 | — | — | 1 | 4.75 |
| CHEMBL3322659 | — | — | 1 | 4.74 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.73 |
| CHEMBL555056 | — | — | 1 | 4.68 |
| CHEMBL3322655 | — | — | 1 | 4.60 |
| CHEMBL3322661 | — | — | 1 | 4.58 |
| CHEMBL3322662 | — | — | 1 | 4.56 |
| CHEMBL3322660 | — | — | 1 | 4.53 |
| CHEMBL1631518 | — | — | 1 | 4.47 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.45 |
| CHEMBL470029 | OLEANONIC ACID | — | 1 | 4.41 |
| CHEMBL1797142 | — | — | 1 | 4.38 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322658 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3322657 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3322656 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL3322659 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL140 | CURCUMIN | IC50 | = | 18520.0 | nM | 4.73 |
| CHEMBL555056 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3322655 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL3322661 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL3322662 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL3322660 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL1631518 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL1797142 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL7890 | L-NAME | IC50 | = | 73180.0 | nM | 4.14 |