Assay Detail
Binding
CHEMBL3370269
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Inhibition of sPLA2-V (unknown origin) using substrate 1,2-bis(heptanoylthio)-glycerophosphocholine by Ellman's method based photometric assay
39
Total Activities
32
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.78 | 6.21 |
| Inhibition | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 6.21 |
| CHEMBL3309949 | — | — | 2 | 5.66 |
| CHEMBL3309948 | — | — | 2 | 5.38 |
| CHEMBL3289927 | — | — | 2 | 5.38 |
| CHEMBL3289926 | — | — | 2 | 5.15 |
| CHEMBL3309947 | — | — | 2 | 5.11 |
| CHEMBL3289925 | — | — | 2 | 5.06 |
| CHEMBL140 | CURCUMIN | 3.0 | 2 | 5.00 |
| CHEMBL3309956 | — | — | 1 | 4.95 |
| CHEMBL3289934 | — | — | 1 | 4.95 |
| CHEMBL3309955 | — | — | 1 | 4.92 |
| CHEMBL3289924 | — | — | 1 | 4.90 |
| CHEMBL3309954 | — | — | 1 | 4.82 |
| CHEMBL3309950 | — | — | 1 | 4.82 |
| CHEMBL3289928 | — | — | 1 | 4.75 |
| CHEMBL3289939 | — | — | 1 | 4.74 |
| CHEMBL3309957 | — | — | 1 | 4.72 |
| CHEMBL3289929 | — | — | 1 | 4.72 |
| CHEMBL3357954 | — | — | 1 | 4.65 |
| CHEMBL3289933 | — | — | 1 | 4.56 |
| CHEMBL3289941 | — | — | 1 | 4.55 |
| CHEMBL3309953 | — | — | 1 | 4.55 |
| CHEMBL3290192 | — | — | 1 | 4.53 |
| CHEMBL3289931 | — | — | 1 | 4.43 |
| CHEMBL3289940 | — | — | 1 | 4.42 |
| CHEMBL3289942 | — | — | 1 | 4.42 |
| CHEMBL3290196 | — | — | 1 | 4.36 |
| CHEMBL3289930 | — | — | 1 | 4.34 |
| CHEMBL3290195 | — | — | 1 | 4.27 |
| CHEMBL3290193 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3309949 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL3309948 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL3289927 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL3289926 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL3309947 | — | IC50 | = | 7790.0 | nM | 5.11 |
| CHEMBL3289925 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL140 | CURCUMIN | IC50 | = | 10120.0 | nM | 5.00 |
| CHEMBL3309956 | — | IC50 | = | 11180.0 | nM | 4.95 |
| CHEMBL3289934 | — | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL3309955 | — | IC50 | = | 12140.0 | nM | 4.92 |
| CHEMBL3289924 | — | IC50 | = | 12570.0 | nM | 4.90 |
| CHEMBL3309950 | — | IC50 | = | 15220.0 | nM | 4.82 |
| CHEMBL3309954 | — | IC50 | = | 15180.0 | nM | 4.82 |
| CHEMBL3289928 | — | IC50 | = | 17780.0 | nM | 4.75 |
| CHEMBL3289939 | — | IC50 | = | 18160.0 | nM | 4.74 |
| CHEMBL3309957 | — | IC50 | = | 19220.0 | nM | 4.72 |
| CHEMBL3289929 | — | IC50 | = | 19220.0 | nM | 4.72 |
| CHEMBL3357954 | — | IC50 | = | 22210.0 | nM | 4.65 |
| CHEMBL3289933 | — | IC50 | = | 27660.0 | nM | 4.56 |
| CHEMBL3289941 | — | IC50 | = | 27990.0 | nM | 4.55 |
| CHEMBL3309953 | — | IC50 | = | 28320.0 | nM | 4.55 |
| CHEMBL3290192 | — | IC50 | = | 29320.0 | nM | 4.53 |
| CHEMBL3289931 | — | IC50 | = | 37290.0 | nM | 4.43 |
| CHEMBL3289940 | — | IC50 | = | 38420.0 | nM | 4.42 |
| CHEMBL3289942 | — | IC50 | = | 37550.0 | nM | 4.42 |
| CHEMBL3290196 | — | IC50 | = | 44120.0 | nM | 4.36 |
| CHEMBL3289930 | — | IC50 | = | 45320.0 | nM | 4.34 |
| CHEMBL3290195 | — | IC50 | = | 54180.0 | nM | 4.27 |
| CHEMBL3290193 | — | IC50 | = | 55720.0 | nM | 4.25 |
| CHEMBL3289932 | — | IC50 | = | 58190.0 | nM | 4.24 |
| CHEMBL3290194 | — | IC50 | = | 67320.0 | nM | 4.17 |
| CHEMBL140 | CURCUMIN | Inhibition | = | 81.5 | % | - |
| CHEMBL3289925 | — | Inhibition | - | % | - | |
| CHEMBL3289926 | — | Inhibition | - | % | - | |
| CHEMBL3289927 | — | Inhibition | - | % | - | |
| CHEMBL3309947 | — | Inhibition | - | % | - | |
| CHEMBL3309948 | — | Inhibition | - | % | - | |
| CHEMBL3309949 | — | Inhibition | - | % | - |