Assay Detail
Binding
CHEMBL3370271
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Inhibition of human recombinant COX2 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.64 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.49 |
| CHEMBL3309948 | — | — | 1 | 5.10 |
| CHEMBL3309949 | — | — | 1 | 5.04 |
| CHEMBL3289925 | — | — | 1 | 4.95 |
| CHEMBL3289933 | — | — | 1 | 4.88 |
| CHEMBL3289930 | — | — | 1 | 4.83 |
| CHEMBL3289941 | — | — | 1 | 4.83 |
| CHEMBL3289939 | — | — | 1 | 4.82 |
| CHEMBL3289924 | — | — | 1 | 4.76 |
| CHEMBL3309947 | — | — | 1 | 4.73 |
| CHEMBL3309950 | — | — | 1 | 4.72 |
| CHEMBL3289931 | — | — | 1 | 4.71 |
| CHEMBL3289926 | — | — | 1 | 4.56 |
| CHEMBL3289942 | — | — | 1 | 4.55 |
| CHEMBL3289929 | — | — | 1 | 4.50 |
| CHEMBL3357954 | — | — | 1 | 4.42 |
| CHEMBL3289927 | — | — | 1 | 4.42 |
| CHEMBL3290193 | — | — | 1 | 4.33 |
| CHEMBL3309953 | — | — | 1 | 4.26 |
| CHEMBL3290194 | — | — | 1 | 4.26 |
| CHEMBL3309957 | — | — | 1 | 4.24 |
| CHEMBL3290196 | — | — | 1 | 4.21 |
| CHEMBL3290192 | — | — | 1 | 4.16 |
| CHEMBL3309956 | — | — | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
| CHEMBL3290195 | — | — | 1 | - |
| CHEMBL3309955 | — | — | 1 | - |
| CHEMBL3309954 | — | — | 1 | - |
| CHEMBL3289928 | — | — | 1 | - |
| CHEMBL3289932 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL3309948 | — | IC50 | = | 7880.0 | nM | 5.10 |
| CHEMBL3309949 | — | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL3289925 | — | IC50 | = | 11210.0 | nM | 4.95 |
| CHEMBL3289933 | — | IC50 | = | 13320.0 | nM | 4.88 |
| CHEMBL3289930 | — | IC50 | = | 14760.0 | nM | 4.83 |
| CHEMBL3289941 | — | IC50 | = | 14850.0 | nM | 4.83 |
| CHEMBL3289939 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3289924 | — | IC50 | = | 17410.0 | nM | 4.76 |
| CHEMBL3309947 | — | IC50 | = | 18550.0 | nM | 4.73 |
| CHEMBL3309950 | — | IC50 | = | 19220.0 | nM | 4.72 |
| CHEMBL3289931 | — | IC50 | = | 19320.0 | nM | 4.71 |
| CHEMBL3289926 | — | IC50 | = | 27650.0 | nM | 4.56 |
| CHEMBL3289942 | — | IC50 | = | 27960.0 | nM | 4.55 |
| CHEMBL3289929 | — | IC50 | = | 31450.0 | nM | 4.50 |
| CHEMBL3289927 | — | IC50 | = | 38210.0 | nM | 4.42 |
| CHEMBL3357954 | — | IC50 | = | 37660.0 | nM | 4.42 |
| CHEMBL3290193 | — | IC50 | = | 46220.0 | nM | 4.33 |
| CHEMBL3309953 | — | IC50 | = | 54320.0 | nM | 4.26 |
| CHEMBL3290194 | — | IC50 | = | 54640.0 | nM | 4.26 |
| CHEMBL3309957 | — | IC50 | = | 57220.0 | nM | 4.24 |
| CHEMBL3290196 | — | IC50 | = | 61230.0 | nM | 4.21 |
| CHEMBL3290192 | — | IC50 | = | 69820.0 | nM | 4.16 |
| CHEMBL3309956 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL3290195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3309955 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3309954 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3289928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3289932 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3289940 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3289934 | — | IC50 | > | 100000.0 | nM | - |