Assay Detail
Binding
CHEMBL3370356
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Inhibition of Chk1 (unknown origin) by luminescent ADP-Glo assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.89 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330232 | — | — | 1 | 8.63 |
| CHEMBL3330227 | — | — | 1 | 8.45 |
| CHEMBL3330148 | — | — | 1 | 8.39 |
| CHEMBL3330230 | — | — | 1 | 8.32 |
| CHEMBL3330133 | — | — | 1 | 8.28 |
| CHEMBL3330233 | — | — | 1 | 8.27 |
| CHEMBL3330229 | — | — | 1 | 8.21 |
| CHEMBL3330236 | — | — | 1 | 8.12 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 8.10 |
| CHEMBL3330234 | — | — | 1 | 8.01 |
| CHEMBL3330135 | — | — | 1 | 8.00 |
| CHEMBL3330136 | — | — | 1 | 7.85 |
| CHEMBL3330231 | — | — | 1 | 7.81 |
| CHEMBL3330132 | — | — | 1 | 7.81 |
| CHEMBL3330235 | — | — | 1 | 7.63 |
| CHEMBL3330237 | — | — | 1 | 7.61 |
| CHEMBL3330228 | — | — | 1 | 7.39 |
| CHEMBL3330134 | — | — | 1 | 7.32 |
| CHEMBL3330138 | — | — | 1 | 6.93 |
| CHEMBL3330141 | — | — | 1 | 6.75 |
| CHEMBL3330145 | — | — | 1 | - |
| CHEMBL3330144 | — | — | 1 | - |
| CHEMBL3330143 | — | — | 1 | - |
| CHEMBL3330142 | — | — | 1 | - |
| CHEMBL3330140 | — | — | 1 | - |
| CHEMBL3330139 | — | — | 1 | - |
| CHEMBL3330137 | — | — | 1 | - |
| CHEMBL3330146 | — | — | 1 | - |
| CHEMBL3330147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330232 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL3330227 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL3330148 | — | IC50 | = | 4.05 | nM | 8.39 |
| CHEMBL3330230 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL3330133 | — | IC50 | = | 5.22 | nM | 8.28 |
| CHEMBL3330233 | — | IC50 | = | 5.36 | nM | 8.27 |
| CHEMBL3330229 | — | IC50 | = | 6.23 | nM | 8.21 |
| CHEMBL3330236 | — | IC50 | = | 7.54 | nM | 8.12 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 7.89 | nM | 8.10 |
| CHEMBL3330234 | — | IC50 | = | 9.84 | nM | 8.01 |
| CHEMBL3330135 | — | IC50 | = | 9.94 | nM | 8.00 |
| CHEMBL3330136 | — | IC50 | = | 14.02 | nM | 7.85 |
| CHEMBL3330231 | — | IC50 | = | 15.34 | nM | 7.81 |
| CHEMBL3330132 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL3330235 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL3330237 | — | IC50 | = | 24.73 | nM | 7.61 |
| CHEMBL3330228 | — | IC50 | = | 40.98 | nM | 7.39 |
| CHEMBL3330134 | — | IC50 | = | 47.5 | nM | 7.32 |
| CHEMBL3330138 | — | IC50 | = | 116.1 | nM | 6.93 |
| CHEMBL3330141 | — | IC50 | = | 177.8 | nM | 6.75 |
| CHEMBL3330145 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330144 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330143 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330140 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330139 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330137 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330146 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3330147 | — | IC50 | > | 10000.0 | nM | - |