Assay Detail
Binding
CHEMBL3370360
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Inhibition of PKC (unknown origin) by Z'-LYTETM kinase assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.13 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330148 | — | — | 1 | 6.77 |
| CHEMBL3330232 | — | — | 1 | 6.69 |
| CHEMBL3330230 | — | — | 1 | 6.41 |
| CHEMBL3330133 | — | — | 1 | 6.28 |
| CHEMBL3330132 | — | — | 1 | 6.16 |
| CHEMBL3330236 | — | — | 1 | 6.09 |
| CHEMBL3330136 | — | — | 1 | 6.00 |
| CHEMBL3330229 | — | — | 1 | 5.70 |
| CHEMBL3330233 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330148 | — | IC50 | = | 168.89 | nM | 6.77 |
| CHEMBL3330232 | — | IC50 | = | 204.48 | nM | 6.69 |
| CHEMBL3330230 | — | IC50 | = | 392.71 | nM | 6.41 |
| CHEMBL3330133 | — | IC50 | = | 522.51 | nM | 6.28 |
| CHEMBL3330132 | — | IC50 | = | 695.85 | nM | 6.16 |
| CHEMBL3330236 | — | IC50 | = | 814.06 | nM | 6.09 |
| CHEMBL3330136 | — | IC50 | = | 1001.81 | nM | 6.00 |
| CHEMBL3330229 | — | IC50 | = | 2018.88 | nM | 5.70 |
| CHEMBL3330233 | — | IC50 | = | 8186.03 | nM | 5.09 |