Assay Detail
Binding
CHEMBL3370549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human CGRP receptor
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.55 | 10.52 |
| Ki | 1 | 9.52 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207197 | OLCEGEPANT | 2.0 | 1 | 10.52 |
| CHEMBL3334624 | BI-44370 | 2.0 | 1 | 9.52 |
| CHEMBL3334623 | — | — | 1 | 7.36 |
| CHEMBL196582 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207197 | OLCEGEPANT | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3334624 | BI-44370 | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3334623 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL196582 | — | IC50 | = | 17000.0 | nM | 4.77 |