Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3370643

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human KB cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Mehndiratta S, Chiang YF, Lai MJ, Lee HY, Chen MC, Kuo CC, Chang CY, Chang JY, Liou JP.
Bioorg Med Chem (2014) 22 : 4917 -4923
PubMed 25059503 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.83 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL90555 VINCRISTINE 4.0 1 9.40
CHEMBL428647 PACLITAXEL 4.0 1 8.48
CHEMBL3325999 1 7.30
CHEMBL3326000 1 7.03
CHEMBL3325998 1 7.00
CHEMBL3325992 1 6.62
CHEMBL3325993 1 6.47
CHEMBL3325997 1 6.38
CHEMBL3325996 1 6.25
CHEMBL3326001 1 6.07
CHEMBL44657 ETOPOSIDE 4.0 1 5.96
CHEMBL3325995 1 5.96
CHEMBL3325994 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL90555 VINCRISTINE IC50 = 0.4 nM 9.40
CHEMBL428647 PACLITAXEL IC50 = 3.3 nM 8.48
CHEMBL3325999 IC50 = 49.7 nM 7.30
CHEMBL3326000 IC50 = 93.5 nM 7.03
CHEMBL3325998 IC50 = 101.0 nM 7.00
CHEMBL3325992 IC50 = 239.0 nM 6.62
CHEMBL3325993 IC50 = 342.0 nM 6.47
CHEMBL3325997 IC50 = 412.0 nM 6.38
CHEMBL3325996 IC50 = 557.0 nM 6.25
CHEMBL3326001 IC50 = 846.0 nM 6.07
CHEMBL44657 ETOPOSIDE IC50 = 1100.0 nM 5.96
CHEMBL3325995 IC50 = 1100.0 nM 5.96
CHEMBL3325994 IC50 = 1200.0 nM 5.92