Assay Detail
Functional
CHEMBL3370644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.26 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3325999 | — | — | 1 | 6.83 |
| CHEMBL3325998 | — | — | 1 | 6.72 |
| CHEMBL3325993 | — | — | 1 | 6.46 |
| CHEMBL3325992 | — | — | 1 | 6.29 |
| CHEMBL3325996 | — | — | 1 | 6.23 |
| CHEMBL3325995 | — | — | 1 | 6.18 |
| CHEMBL3326000 | — | — | 1 | 6.17 |
| CHEMBL3325994 | — | — | 1 | 6.09 |
| CHEMBL3325997 | — | — | 1 | 6.01 |
| CHEMBL3326001 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3325999 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3325998 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL3325993 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL3325992 | — | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL3325996 | — | IC50 | = | 588.0 | nM | 6.23 |
| CHEMBL3325995 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL3326000 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL3325994 | — | IC50 | = | 803.0 | nM | 6.09 |
| CHEMBL3325997 | — | IC50 | = | 968.0 | nM | 6.01 |
| CHEMBL3326001 | — | IC50 | = | 2377.0 | nM | 5.62 |