Assay Detail
Functional
CHEMBL3370887
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Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.95 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 9.40 |
| CHEMBL329993 | EPOTHILONE A | — | 1 | 9.10 |
| CHEMBL3326009 | — | — | 1 | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.52 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.30 |
| CHEMBL3326011 | — | — | 1 | 7.22 |
| CHEMBL3326015 | — | — | 1 | 6.30 |
| CHEMBL3326013 | — | — | 1 | 6.10 |
| CHEMBL3326010 | — | — | 1 | 5.82 |
| CHEMBL3326017 | — | — | 1 | 5.06 |
| CHEMBL3326014 | — | — | 1 | 4.70 |
| CHEMBL3326016 | — | — | 1 | 4.35 |
| CHEMBL3326012 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3326009 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3326011 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3326015 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3326013 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3326010 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL3326017 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3326014 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL3326016 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL3326012 | — | IC50 | = | 110800.0 | nM | - |