Assay Detail
Functional
CHEMBL3370888
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Cytotoxicity against human A549 cells after 48 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.33 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.23 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.09 |
| CHEMBL3326009 | — | — | 1 | 6.31 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.89 |
| CHEMBL3326011 | — | — | 1 | 5.12 |
| CHEMBL3326010 | — | — | 1 | - |
| CHEMBL3326012 | — | — | 1 | - |
| CHEMBL3326013 | — | — | 1 | - |
| CHEMBL3326014 | — | — | 1 | - |
| CHEMBL3326015 | — | — | 1 | - |
| CHEMBL3326016 | — | — | 1 | - |
| CHEMBL3326017 | — | — | 1 | - |
| CHEMBL329993 | EPOTHILONE A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3326009 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3326011 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL3326010 | — | IC50 | - | — | - | |
| CHEMBL3326012 | — | IC50 | - | — | - | |
| CHEMBL3326013 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3326014 | — | IC50 | - | — | - | |
| CHEMBL3326015 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3326016 | — | IC50 | - | — | - | |
| CHEMBL3326017 | — | IC50 | - | — | - | |
| CHEMBL329993 | EPOTHILONE A | IC50 | > | 5000.0 | nM | - |