Assay Detail
Binding
CHEMBL3371009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional epoxide hydrolase 2 (CHEMBL5669) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.79 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3327064 | — | — | 1 | 8.74 |
| CHEMBL3327077 | — | — | 1 | 7.88 |
| CHEMBL3327078 | — | — | 1 | 7.70 |
| CHEMBL1258904 | — | — | 1 | 7.54 |
| CHEMBL1668934 | — | — | 1 | 7.10 |
| CHEMBL3327067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3327064 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3327077 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL3327078 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1258904 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL1668934 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3327067 | — | IC50 | < | 1.25 | nM | - |