Assay Detail
Binding
CHEMBL3371144
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin D (unknown origin)
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based optimization of non-peptidic Cathepsin D inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.78 | 7.07 |
| Ki | 1 | 9.15 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81927 | — | — | 2 | 9.15 |
| CHEMBL68595 | — | — | 1 | 6.68 |
| CHEMBL83114 | — | — | 1 | 6.60 |
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81927 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL81927 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL68595 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL83114 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL296588 | PEPSTATIN | IC50 | < | 1.0 | nM | - |